Mối liên hệ ẩn giấu giữa rượu và ung thư trực tràng: Những điều bạn cần biết

 Một nghiên cứu gần đây trên 137.710 người tham gia trong ba thập kỷ cho thấy ngay cả việc tiêu thụ rượu ở mức nhẹ đến trung bình cũng có liên quan đến việc tăng nguy cơ ung thư trực tràng (CRC), đặc biệt là ở nam giới.

findings suggest that:

Tổng lượng rượu tiêu thụ quan trọng hơn tần suất uống hoặc loại đồ uống. HR (95% CI) đối với nhóm tuổi từ 5-14,9 và 15-29,9 so với nhóm tuổi uống 0 g/ngày là 1,19 (1,01 đến 1,41) và 1,38 (1,13 đến 1,67). ✅ Nguy cơ vẫn tồn tại trong nhiều năm—ngay cả những người từng uống rượu cũng không thấy nguy cơ mắc CRC giảm đáng kể sau 10 năm cai thuốc ✅ Khoảng cách thời gian giữa lượng rượu tiêu thụ và tỷ lệ mắc CRC ước tính là 8-12 năm, làm nổi bật tác động lâu dài của thói quen uống rượu

https://academic.oup.com/jnci/advance-article/doi/10.1093/jnci/djae330/7926885?login=false

he findings suggest that:

Total alcohol intake matters more than drinking frequency or beverage type. HR (95% CI) for 5-14.9 and 15-29.9 vs 0 g/day of alcohol intake was 1.19 (1.01 to 1.41) and 1.38 (1.13 to 1.67).

Risk persists for years—even former drinkers didn’t see a significant reduction in CRC risk after 10 years of quitting

The time lag between alcohol consumption and CRC occurrence is estimated at 8-12 years, highlighting the long-term impact of drinking habits

Abstract

Background

Association between light to moderate alcohol consumption and colorectal cancer (CRC) incidence remains understudied, especially regarding drinking pattern, beverage type, and temporal aspects.

Methods

Hazard ratios (HRs) and 95% confidence intervals (CIs) for time to CRC diagnosis were estimated among 137 710 participants. Estimates based on remote (eg, >10 years before follow-up) and recent (eg, the preceding 10 years before follow-up) alcohol intake, using different cutoffs (eg, 8, 10, 12 years) and mutual adjustment, enabled separating independent effects and investigating time lag of alcohol–CRC association.

Results

In total, 3599 CRC cases were documented over 3 decades. Light to moderate drinking was associated with an increased CRC risk only in men: HR (95% CI) for 5-14.9 and 15-29.9 vs 0 g/day of alcohol intake was 1.19 (1.01 to 1.41) and 1.38 (1.13 to 1.67). In women, that for 0.1-4.9 and 5-14.9 vs 0 g/day of alcohol was 1.07 (0.96 to 1.20) and 1.05 (0.91 to 1.20). Drinkers with both high drinking frequency and daily intake had the highest CRC risk, suggesting total alcohol intake was the critical factor. We estimated the time lag between alcohol consumption and CRC occurrence to be 8 to 12 years. Former drinkers did not experience a significant reduction in CRC risk even after 10 years of quitting or reducing consumption.

Conclusions

Based on 2 cohorts of health professionals, our findings suggest that the increased risk of CRC associated with alcohol intake is driven mainly by total quantity and remote intake. Former drinkers did not experience an immediate reduction in CRC risk after quitting or reducing consumption.